Evolutionary conservation analysis
The evolutionary conservation analysis of the amino acids encoded by the new pathogenicity sites in ABC genes were performed among vertebrates, including Gibbon, Macaque, Olive baboon, Gelada, Marmoset, Mouse, Rat, Cow, Sheep, Pig, Chicken, Zebra finch, Zebrafish, etc, using the genomic alignments of the Ensembl Genome Browser.