Figure 5. Strong blood cytokine storm signature in COVID-MDR.
A, 4-component PCA clustering of blood proteome differentiates between blood samples from patients with COVID-MDR, DRESS, MDR, and HC.B, The Venn diagram depicts the shared or unique differentially regulated proteins in the serum (p <= 0.05, |L2FC| >= 1) between each indicated comparison. C, Heatmap depicts all proteins shown in the Venn diagram. p- value and logFC between COVID-MDR and DRESS are shown in the table on the right. *; p <= 0.05, **; p<= 0.01. D, Box plots of selected inflammatory markers are shown. Normalized protein expression (NPX) are shown in Log2 scale. *; p <= 0.05, **; p <= 0.01.