Methods
This was a systematic review/meta-analysis conducted in Medline (OVID),
Embase, Scopus, Cochrane library and medRxiv from inception to
22nd May-2020. English studies that evaluated the
effect of ACEIs/ARBs among patients with COVID-19 were included. The
study outcomes included any COVID-19 related-clinical outcomes. Studies’
quality was appraised using the Newcastle-Ottawa Scale. Data were
analysed using the random-effects modelling stratified by ACEIs/ARBs,
ACEIs, and ARBs. Heterogenicity was assessed using I2statistic. Several sub-group analyses were conducted to explore the
impact of potential confounders.