Strengths and limitation
We believe this study is the first to provide a systematic,
comprehensive and updated evaluation of the effects of ACEIs/ARBs on all
the reported COVID-19 related clinical outcomes including exploration of
inter-class differences between ACEIs and ARBs as well as multiple
sub-group analyses. However, our study has limitations. Since all
included studies were observational studies, the effect of confounding
including residual confounders cannot be ruled out. There is also the
possibility that new studies have been published since our review.
However, we included non-peer reviewed articles published in medRxiv to
help address this.