Methods
An umbrella literature review and subsequent meta-analysis was conducted. The protocol was informed by Joanna Briggs Reviewer’s Manual for ‘Development of an Umbrella review protocol’ (8) and published on PROSPERO (CRD42021233398).
Eligibility criteria
Eligible studies were systematic reviews which conducted a meta-analysis to explore the effect of ACEIs/ARBs on any COVID-19 related clinical outcomes among adults (≥18 years) with COVID-19 diagnosis.