Rash type (n) Clinical presentation (n) Corresponding histopathological features (n) Grade, n Grade, n Grade, n Grade, n
1 2 3 4
Maculopapular (33)
Scattered edematous macules and/or red papules Trunk-predominant (14), Extremity-predominant (8), trunk alone (6), extremities alone (5)
Vacuolar degeneration at the DEJ (33), perivascular lymphocytic infiltration (33), eosinophilic infiltration (27), epidermal spongiosis (12), necrotic keratinocytes (13), small abscess in the epidermis (1)
22
9
2
0
EM (2) Erythematous macules with target lesion or iris formation, scattered on the trunk and proximal extremities (2) Vacuolar degeneration at the DEJ (2), perivascular lymphocytic infiltration (2), eosinophilic infiltration (2), epidermal spongiosis (1), necrotic keratinocytes (1) 0 2 0 0
Lichenoid (3) Pink-to-violaceous papules and plaques with scales, predominantly on the extremities (3), oral ulcer and leukoplakia (1) Dense lymphocytic infiltration at the DEJ (lichenoid infiltration) (3), infiltration of a few eosinophils (3), necrotic keratinocytes (3), acanthosis (2), thickened granular layer (2), orthohyperkeratosis (2), and epidermal spongiosis (2) 3 0 0 0
Psoriasiform (1) Plaque psoriasis on the trunk and extremities, with no pustulosis, scalp lesions, or arthritis (1) Parakeratosis, acanthosis, diminished granular layer, elongated rete ridges, intraepidermal bullae containing neutrophils, mild vacuolar degeneration at the DEJ, and perivascular infiltration of lymphocytes, eosinophils, and neutrophils in the upper dermis (1) 0 1 0 0
BP (1)
Broken bullae with erythematous macules on the chest and abdomen (1)
Subepidermal bulla containing eosinophils, perivascular infiltration of lymphocytes and eosinophils (1), linear deposition of IgG and C3 at the DEJ on DIF (1)
1
0
0
0
Scleroderma-like (1) Skin sclerosis of the fingers (1) Increased thick collagen bundles packing sweat glands (1) 1 0 0 0
SJS (1) Erythematous macules scattered on the trunk and proximal extremities, mucosal ulcerations, the Nikolsky sign (1) Epidermal necrosis with numerous necrotic keratinocytes, acantholytic bullae, infiltration of lymphocytes and eosinophils, and parakeratotic hyperkeratosis (1) 0 0 1 0
Total 27 12 3 0