Introduction
Whole genome sequencing (WGS) has been essential to clarify a key aspect in the COVID-19 pandemic, namely, the analysis of recurrences, allowing to identify which are due to reinfections (Mulder et al., 2020; Tillett et al., 2020). Genomic research has demonstrated the prolonged persistence of viable SARS-CoV-2 in severely immunosuppressed patients (Baang et al., 2020; Choi et al., 2020), but it has not equally been used to support reactivations, and the scarce reports focus primarily on clinical descriptions (Coppola, Annunziata, Carannante, Di Spirito, & Fiorentino, 2020). Furthermore, the potential relationship between SARS-CoV-2 reactivation and associated nosocomial outbreaks has not been described to date. In this study we present a SARS-CoV-2 reactivation and its consequences in the nosocomial setting.