Effect of LCZ on E. coli-induced impairment of
mammary tissue in mice
The mammary tissues in the Control and LCZ groups were smooth and white
without any redness or swelling (Figure 5A). Redness and bleeding were
visible in the E. coli group; however, in the LCZ + E.
coli group, the redness and hemorrhage of the mammary tissue of mice
were visibly relieved. A significant reduction in the injury score was
observed in the LCZ + E. coli group compared with the E.
coli group. No significant difference in the injury score was observed
among the LCZ + E. coli , LCZ, and Control groups.
No visible pathological damage was observed in the mammary acinar
structure of the mice in the Control and LCZ groups. However, observable
pathological injury was evident in mammary acini in the E. coligroup. In addition to damage to mammary acini structure, there was a
large number of neutrophils in the alveolar lumen; in contrast, in the
LCZ + E. coli group, damage to the mammary acinar structure and
the number of neutrophils were visibly alleviated. A significant
decrease in the histological score was observed in the LCZ + E.
coli group relative to the E. coli group. No significant
difference in the injury score was detected between the LCZ and Control
groups.