Effect of LCZ on the transcriptional levels of
inflammatory cytokines of BMECs
The effect of LCZ on the transcriptional levels of inflammatory
cytokines of BMECs is shown in Figure 4. The expression of TNF-α, IL-6,
and IL-β was significantly up-regulated in the E. coli group
relative to other groups. Although the expression levels of three
inflammatory cytokines in the LCZ + E. coli group were
significantly higher than those observed in the Control and LCZ groups,
the expression levels of these cytokines were all significantly lower in
these three groups relative to the E. coli group.