Effect of LCZ on the expression of the tight junction
proteins of BMECs
The expression of tight junction proteins of BMECs, such as claudin-1,
claudin-4, occluding, and zonula occludins-1 (ZO-1), were significantly
down-regulated by E. coli compared with other groups (Figure 3).
Meanwhile, the expression of the four proteins was significantly
up-regulated in the LCZ + E. coli group relative to the E.
coli group. The expression of ZO-1 in the LCZ group was significantly
higher than the expression of ZO-1 observed in the Control group; no
significant differences were detected in the expression levels of the
other three proteins compared with the Control group.