Effect of LCZ on the transcriptional levels of inflammatory cytokines of BMECs
The effect of LCZ on the transcriptional levels of inflammatory cytokines of BMECs is shown in Figure 4. The expression of TNF-α, IL-6, and IL-β was significantly up-regulated in the E. coli group relative to other groups. Although the expression levels of three inflammatory cytokines in the LCZ + E. coli group were significantly higher than those observed in the Control and LCZ groups, the expression levels of these cytokines were all significantly lower in these three groups relative to the E. coli group.