Results
Six cases with AFLP and 48 women with HELLP syndrome were included into
the study. Patients with AFLP showed significantly higher sFlt-1 levels
(median: 57570pg/ml [range: 31609-147170pg/ml]) than patients with
HELLP syndrome (9713pg/ml [1348-30781pg/ml ; p<0.001). PLGF
serum levels were increased in patients with AFLP compared to those with
HELLP syndrome (197 pg/ml [127-487pg/ml] versus 40 pg/ml
[9-644pg/ml], respectively, p<0.01,). sFlt-1/PLGF-ratios
were not significantly different between AFLP and HELLP syndrome
patients (192 [157-1159] versus 232 [3-948], respectively, NS).
A sFlt-1 cut-off value of 31100pg/ml allowed differentiating between
these two diseases with a sensitivity and specificity of 100%.