Conclusion
In conclusion, our findings confirm that the presence of
antiphospholipid antibodies in women with early-onset preeclampsia with
severe features is associated with earlier, more severe multi-organ
involvement. Early screening for
aPL antibodies in cases of preeclampsia should be encouraged, and
optimal combination therapy, in the current or the following pregnancy,
should be considered in women with positive aPL antibodies to improve
pregnancy outcomes. To generalize our conclusions and search for
causality in the association between aPL antibodies and the severity of
preeclampsia, high quality prospective multicenter randomized control
study should be conducted.
Acknowledgments: None.
Disclosure of Interests: The authors report no conflict of
interest.
Ethics approval: The study protocol was approved by the
Institutional Review Board at the Sheba Medical Center (9683-12-SMC) on
June 09, 2015, and written informed consent was obtained from all
participants.
Funding: None
Contribution to
Authorship
RZ - Substantial contribution to acquisition, analysis and
interpretation of data
Drafting the article submitted and revising it for important
intellectual content
Approval of the final version to be published
MB - Drafting the article submitted and revising it for important
intellectual content
Approval of the final version to be published
HOF - Substantial contribution to acquisition, analysis and
interpretation of data; Approval of the final version to be published
IM - Substantial contribution to conception and design of the project
Substantial contribution to acquisition, analysis and interpretation of
data
Approval of the final version to be published
MD - Substantial contribution to conception and design of the project
Substantial contribution to acquisition, analysis and interpretation of
data
Drafting the article submitted and revising it for important
intellectual content
Approval of the final version to be published
MJS - Substantial contribution to conception and design of the project
Substantial contribution to acquisition, analysis and interpretation of
data
Drafting the article submitted and revising it for important
intellectual content
Approval of the final version to be published