Conclusion
In conclusion, our findings confirm that the presence of antiphospholipid antibodies in women with early-onset preeclampsia with severe features is associated with earlier, more severe multi-organ involvement. Early screening for aPL antibodies in cases of preeclampsia should be encouraged, and optimal combination therapy, in the current or the following pregnancy, should be considered in women with positive aPL antibodies to improve pregnancy outcomes. To generalize our conclusions and search for causality in the association between aPL antibodies and the severity of preeclampsia, high quality prospective multicenter randomized control study should be conducted.
Acknowledgments: None.
Disclosure of Interests: The authors report no conflict of interest.
Ethics approval: The study protocol was approved by the Institutional Review Board at the Sheba Medical Center (9683-12-SMC) on June 09, 2015, and written informed consent was obtained from all participants.
Funding: None
Contribution to Authorship
RZ - Substantial contribution to acquisition, analysis and interpretation of data
Drafting the article submitted and revising it for important intellectual content
Approval of the final version to be published
MB - Drafting the article submitted and revising it for important intellectual content
Approval of the final version to be published
HOF - Substantial contribution to acquisition, analysis and interpretation of data; Approval of the final version to be published
IM - Substantial contribution to conception and design of the project
Substantial contribution to acquisition, analysis and interpretation of data
Approval of the final version to be published
MD - Substantial contribution to conception and design of the project
Substantial contribution to acquisition, analysis and interpretation of data
Drafting the article submitted and revising it for important intellectual content
Approval of the final version to be published
MJS - Substantial contribution to conception and design of the project
Substantial contribution to acquisition, analysis and interpretation of data
Drafting the article submitted and revising it for important intellectual content
Approval of the final version to be published