Data extraction
We extracted following required data using a pre-designed standardized electronic form (Excel, Microsoft Office): first author’s name, publication year and country, research design, age and gender of subjects, sample size, duration of intervention and soy dose. Also, we extracted mean and standard deviation (SD) of plasma adipokines status (adiponectin and leptin) at baseline and after the intervention. Any reported standard errors of mean (SEM), were converted to SDs through following formula by SD = SEM × √n (n is the number of participants in each group). Finally, in studies which reported data in graphical figures, data extraction was performed by using GetData Graph Digitizer 2.24 29.