Outcome assessment
Overall survival (OS) and event-free survival (EFS) were the primary
endpoints. OS was defined as the period from date of diagnosis to death
due to any cause. EFS was defined as the period from the date of
diagnosis to relapse, progression, or death. Complete remission (CR) of
primary disease was defined as the absence of mediastinal disease on
radiological examination. Bone marrow blasts <5% in those
with initial marrow involvement was also needed to define CR. Partial
remission (PR) was defined as residual disease on radiological
examination and /or bone marrow blasts 5-25%.