Cannabigerol |
DNBS-induced colitis |
Decrease NO production in
macrophages and ROS formation in intestinal epithelial cells (Borrelli
et al., 2013) |
Cannabichromene |
DNBS-induced colitis |
Inhibits NO production in
macrophages (Romano et al., 2013) |
WIN 55,212-2
|
DSS-induced colitis
|
Partly inhibits of p38
MAPK (Feng et al., 2016)
|
HU210
|
DSS-induced colitis and DNBS-induced colitis
|
Maintains intestinal barrier integrity independent of TLR4, but produces
extraintestinal anti-inflammatory effects that via
TLR4-mediated p38 MAPK activation (Lin et al., 2017, Massa et al.,
2004)
|
Palmitoylethanolamide |
DSS-induced colitis and DNBS-induced colitis |
Inhibits intestinal inflammation and maintains barrier integrity via
activation of CB2, GPR55 and modulation of
inflammation-associated VEGF signaling via the Akt/mTOR pathway in a
selective PPARα-dependent manner (Borrelli et al., 2015;
49-52) |