2.0 Endocannabinoid system
Endocannabinoid system is a neuromodulator system that consists of
endogenous cannabinoids such as 2-arachidonoylglycerol and anandamide,
their cognate receptors (CB1 and CB2),
and the enzymes involved their synthesis (phospholipase C-β (PLC β) and
1,2-diacylglycerol lipase) and inactivation (monoglyceride lipase and
fatty acid amide hydrolase) (Argenziano et al., 2019; Bie et al., 2018).
This neuromodulatory system is important in maintaining immune system
homeostasis, as well as inflammatory processes. Of the two cannabinoid
receptors, CB2, to a greater extent, is involved in the
regulation of immune response compared to CB1 receptors
(Argenziano et al., 2019).