2.0 Endocannabinoid system
Endocannabinoid system is a neuromodulator system that consists of endogenous cannabinoids such as 2-arachidonoylglycerol and anandamide, their cognate receptors (CB1 and CB2), and the enzymes involved their synthesis (phospholipase C-β (PLC β) and 1,2-diacylglycerol lipase) and inactivation (monoglyceride lipase and fatty acid amide hydrolase) (Argenziano et al., 2019; Bie et al., 2018). This neuromodulatory system is important in maintaining immune system homeostasis, as well as inflammatory processes. Of the two cannabinoid receptors, CB2, to a greater extent, is involved in the regulation of immune response compared to CB1 receptors (Argenziano et al., 2019).