Ethics statement

All applicable animal welfare regulations, including EU Directive 2010/63/EC and institutional guidelines, were taken into consideration in the present study. The animal experiments were approved by the State Office for Agriculture, Food Safety and Fishery in Mecklenburg-Western Pomerania (LALFF M-V) under reference numbers LALLF 7221.3-1.1-064/17 and LALLF 7221.3-2-011/19.