References
  1. Bluestone CD,Klein J. Definitions,terminology and classification.In: Otitis Media in Infants and Children (Second Edition).Bluestone CD, Klein JO (Eds).WB Saunders Company, PA,USA,1-3 (1995).
  2. Pau BC,Ng DK.Prevalence of otitis media with effusion in children with allergic rhinitis,a cross sectional study[J].Int J Pediatr Otorhinolaryngol,2016,84:156-160.doi: 10.1016 /j.ijporl.2016.03.008.
  3. Chantzi FM,Kafetzis DA,Bairamis T,et al.IgE sensi- tization,respiratory allergy symptoms,and heritability independently increase the risk of otitis media with effusion[J].Allergy,2006,61(3):332-336.doi: 10.1111/j.1398-9995.2006.00971.x.
  4. DENG Huiyi,YANG Qintai,WANG Weihao,et al.In- cidence of otitis media with effusion in adenoid hypertro- phy with allergic rhinitis in children[J].Journal of Sun Yat-Sen University(Medical Sciences),2017,38(1):101-105.doi:10.13471 /j.cnki.j.Sun.yat-sen.univ ( med.sci).2017.0016.
  5. Wright HD, Hurst D, Miotto D,et al. Increased expression of major basic protein and interleukin-5 in middle ear biopsy specimens from atopic patients with persistent otitis media with effusion.Otolaryngol Head Neck Surg,2000,123:533-538.
  6. Jang CH,Kim YH.Characterization of cytolines present in pediatric otitis media with effusion:comparision of allergy positive and negative.Int J Pediatr Otorhinolaryngol,2002,66:37-40.
  7. Nonaka M,Fukumoto A,Ozu C,et al.IL-5 and eotaxin levels in middle ear effusion and blood from asthmatics with otitis media with effusion.Acta Otolaryngol,2003,123:383-387.
  8. Zhang L L.Effects of Yufeng Powder hesheng Decoction on Th17 /Treg cytokines in peripheral blood of patients with bronchial asthma[J].Journal of Modern Integrated Traditional Chinese and Western Medicine,2017,26( 28):3104-3106.
  9. Xiao ling Zou,Zhuang gui Chen,Tian tuo Zhang,et al.Th17/Treg homeostasis,but not Th1/Th2 homeostasis is implicated in exacerbation of human bronchial asthma[J].Ther Clin Risk Manag,2018,14:1627-1636.
  10. Hardy SM,Heavner SB,White DR,et al.Late-phase allergy and eustachian tube dysfunction.Otolaryngol Head Neck Surg,2001,125(4):339-345.
  11. Yellon RF,Leonard G,Marucha P,etal.Demonstration of interleukin 6 in middle ear effusions.Arch 0tolaryngol Head Neck Surg,1992,118(7):745-748.
  12. Doy le W J.The link between alle rgic rhinitis and otitis media.CurrOpin Alle rgy C lin Immuno l,2002,2:21-25.
  13. Sobol SE,Taha R,Schloss MD,et al.Th2 cytokine expression in atopic children with otitis media with effusion. J Allergy Clin Immunol,2002,110(1):125-130.
  14. Wright HD, Hurst D, Miotto D,et al.Increased expression of major basic protein and interleukin-5 in middle ear biopsy specimens from atopic patients with persistent otitis media with effusion.Otolaryngol Head Neck Surg,2000,123:533-538.
  15. Jang CH,Kim YH.Characterization of cytolines present in pediatric otitis media with effusion::comparision of allergy positive and negative.Int J Pediatr Otorhinolaryngol,2002,66:37-40.
  16. Nonaka M,Fukumoto A,Ozu C,et al.IL-5 and eotaxin levels in middle ear effusion and blood from asthmatics with otitis media with effusion. Acta Otolaryngol,2003,123:383-387.
  17. Xiao ling Zou,Zhuang gui Chen,Tian tuo Zhang,et al.Th17 /Treg homeostasis,but not Th1/Th2 homeostasi,is implicated in exacerbation of human bronchial asthma[J].Ther Clin Risk Manag,2018,14:1627-1636.
  18. YANG Qintai.Paying attention to the‘lateral airway‘allergic diseases in children[J].J Otolaryngol Ophthalmol Shandong Univ,2019,33( 1):59-62.
  19. Kimura A,Kishimoto T.IL-6:regulator of Treg/Th17 balance.Eur J Immunol. 2010,40(7):1830-1835. doi: 10.1002/eji.201040391.
  20. LI Ying,ZHAO Shouqin.Advances in clinical research on otitis media with effusion and allergic rhinitis in children[J].Chinese Journal of Otology,2016,14(2):295-29.
  21. ZENG H,CHI H.mTOR signaling in the differentiation and function of regulatory and effector T cells[J].Curr Opin Immunol,2017,46:103-111.
  22. CHEN Yc,LlAo F.CXCR3 signaling in glial cells ameliorates experimental autoimmune encephalomyelitis by restraining the generation of a pro-Thl7 cytokine milieu and reducing CNS-infihrating Th17 cells[J].J Neuroinflamm,2016,13(1):1-17.
  23. LOPALCO G,LUCHERINl M,LOPALCO A,et al.Cytokine signatures in mucocutaneous and ocular Behcet‘s disease[J].Front Immunol,2017,8:200.
  24. CHEN LC,NICHOLSON YT,ROSBOROUGH BR,et al.A Novel mTORCl-dependent.Akt-independent pathway differentiates the gut tropism of regulatory and conventional CD4 T cells[J].J Immunol,2016,197(4):1137-1147.
  25. PERL A.Activation of mTOR(mechanistic target of rapamycin) in rheumatic diseases[J].Nat Rev Rheumatol,2016,12(3):169—182.
  26. PERL A.mTOR activation is a biomarker and a central pathway to autoimmune disorders,cancer,obesity,and aging[J].Ann N YAcad Sci,2015,1346(1):33-44.Conflict of InterestThe authors confirm that there are no conflicts of interest.AcknowledgementThis work was supported by the Health science and Technology program of Shenzhen Longgang District(LGKCYLWS2019000227) and theShenzhen Key Medical Discipline Construction Fund(No.SZXK039).Ethics StatementThis animal experiments and the human studies informed consent of all participating subjects was obtained conform to internationally accepted standards and have been approved by the appropriate institutional review body.