3.4 OME animal model showed activated PI3K/Akt/mTOR signaling
Western Blot detection of PI3K/Akt/mTOR pathway related protein
expression (Figure 8) showed that compared with CON group, OME group had
significantly increased p-mTOR and p-PI3K protein expression, suggesting
that under the stimulation of allergens, phosphorylation of PI3K and
mTOR occurs locally in the mucosa of the middle ear, and the
PI3K/Akt/mTOR pathway is activated, resulting in the imbalance of
Treg/Th17 and the local immune response of the middle ear.