Conclusion

we found that the imbalance of the thl7 / Treg may be one of the important link of OME and the classic PI3K/Akt/mTOR signaling pathway may be involved in regulating T cell differentiation. Our study provides new insights into the etiological mechanisms of immunity and allergy with OME. In addition, mTOR inhibitors have been used to study the treatment of autoimmune diseases such as RA and SLE [25-26].Therefore, mTOR targeted therapy is expected to be a novel approach to treat OME in the future.