Conclusion
we found that the imbalance of the thl7 / Treg may be one of the
important link of OME and the classic PI3K/Akt/mTOR signaling pathway
may be involved in regulating T cell differentiation. Our study provides
new insights into the etiological mechanisms of immunity and allergy
with OME. In addition, mTOR inhibitors have been used to study the
treatment of autoimmune diseases such as RA and SLE
[25-26].Therefore, mTOR targeted therapy is expected to be a novel
approach to treat OME in the future.