2. The expression of RORγt mRNA and Foxp3mRNA in PBMC of PC group was different from NC group
The expression of RORγT mRNA and Foxp3 mRNA in PC group and NC group were detected by PCR and showed increased levels in PC group (P<0.05), Foxp3 mRNA expression in PC group was lower than NC group (P<0.05). In addition, OME patients had systemic sensitization caused by Treg/Th17imbalance, which may create conditions for local excitation of the middle ear.
3. Abnormal immune response inOME animal model;