2. The expression of RORγt mRNA and Foxp3mRNA in PBMC of PC
group was different from NC group
The expression of RORγT mRNA and
Foxp3 mRNA in PC group and NC group were detected by PCR and showed
increased levels in PC group (P<0.05), Foxp3 mRNA expression
in PC group was lower than NC group (P<0.05). In addition, OME
patients had systemic sensitization caused by Treg/Th17imbalance, which
may create conditions for local excitation of the middle ear.
3. Abnormal immune response inOME animal model;