3.3 Latency of onset of rash to detection of human herpes viruses
We trended the days from the onset of rash to the first detection of the
herpesviruses with a normal distribution as shown in Figure 1. The peak
time from onset of disease to viral reactivation was around 11 days for
EBV, 16 days for HHV6, and 23 days for CMV.
3.4 Predisposing factors for viral reactivation DRESS
patients
To identify potential predisposing factors for viral reactivation, a
comparative analysis of baseline characteristics between viral
reactivated (n=39) and non-reactivated (n=54) groups was performed.(Supp
Table 1) Our results showed that viral reactivation occurred independent
of demographics, baseline co-morbidities, culprit drug and treatment. Of
note, viral reactivation was observed in 15 out of 41 patients (37%)
treated with topical steroids compared to 24 out of 49 (49%) patients
treated with systemic corticosteroids (p=0.24).
3.5 Viral reactivation on DRESS phenotype and
outcomes