INTRODUCTION
Infection due to diverse organisms during induction chemotherapy for acute leukemia is often encountered due to immunosuppression. Severe bone and soft tissue infection due to non-tuberculous mycobacteria (NTM) in leukemic patient is possible but rare. Here we report a case of acute myeloid leukemia (AML) complicated with right calcaneal osteomyelitis due to Mycobacterium abscessus with subcutaneous abscesses extending to popliteal and groin regions requiring multiple operations and prolonged anti-mycobacterial therapy.