3. Challenges in management of NTM infection
Surgical debridement was the mainstay of treatment for bone and soft tissue infection (17) with prolonged anti-mycobacterial treatment in terms of at least 6 to 12 months (17-19). Drug-related toxicities and development of drug resistance may be encountered. As in our patient, antibiotics had to be stopped in view of drug-related rash and liver toxicity. Experience on use of bedaquiline and clofazimine as salvage therapy was limited without efficacy and safety profile for paediatric population documented in literature (20). Meticulous counselling of patient and parents before usage and close monitoring of potential side effects and drug interactions were crucial.