2.2. Carbapenems consumption:
The carbapenem consumption data in ICU over the study period including meropenem and imipenem expressed as a daily defined dose (DDD) / 1000 patient-days, a unit recommended from WHO, were daily collected during the study period. It was calculated as the amount of meropenem and imipenem consumed in each day by the gram, divided by 2, and the number of patients then multiplied by 1000 (Sketris et al., 2004).