2.2. Carbapenems consumption:
The carbapenem consumption data in ICU over the study period including
meropenem and imipenem expressed as a daily defined dose (DDD) / 1000
patient-days, a unit recommended from WHO, were daily collected during
the study period. It was calculated as the amount of meropenem and
imipenem consumed in each day by the gram, divided by 2, and the number
of patients then multiplied by 1000 (Sketris et al., 2004).