Animals
Female Balb/c mice (6 weeks old , 18.1±1.4g) were housed in specific pathogen-free (SPF) conditions at 21 to 24 °C and 40% to 60% relative humidity with a 12 h light-dark cycle. All the animals were acclimatized for at least one week prior to the start of the experiments. All studies were performed in accordance with the guidelines for animal experimentation by Wonkwang University and were approved by the university’s Institutional Animal Care and Use Committee (Approval No. WKU13-50, WKU18-43).