Body and splenic weights
The body weights of the animals were carefully monitored. Only slight changes in the weights from Day 0 to Day 28 were seen and may be attributed to differences in the metabolic activity of the animals (data not shown). The spleen weights (collected on Day 28) were measured to assess their in vivo immunomodulatory status following administration of antigen (OVA) in the presence or absence ofMorus alba L. or CT treatments. A significant increase in the spleen weights was seen following treatment with OVA and Morus alba L. or CT and Morus alba L. compared to the OVA alone group (Fig 2A).