Data analysis
The data and statistical analysis comply with the recommendations of the British Journal of Pharmacology on experimental design and analysis in pharmacology (Curtis et al., 2018). Sample sizes subjected to statistical analysis at least n = 10, where n = number of independent values. Data are expressed as the mean ± SD, and statistical significance was determined by analysis of variance and Student’s t -tests. P -values < 0.05 were considered statistically significant.