Article Type: News and Views: Groundbreaking Discoveries in
Immunology
Title: Emollients for the prevention of atopic dermatitis
Authors: Akash Kothari1(https://orcid.org/0000-0003-1980-161X), Arielle
Locke2,
Thomas Eiwegger1,3,4(https://orcid.org/0000-0002-2914-7829)
1Translational Medicine Program, Research Institute,
Hospital for Sick Children, Toronto, Ontario, Canada
2Department of Medicine, National University of
Ireland, Galway, Ireland
3Division of Immunology and Allergy, Food Allergy and
Anaphylaxis Program, The Department of Pediatrics, Hospital for Sick
Children, Toronto, Ontario, Canada
4Department of Immunology, Faculty of Medicine,
University of Toronto, Toronto, Ontario, Canada
Correspondence to: Thomas Eiwegger, MD, Division of Immunology
and Allergy, Food Allergy and Anaphylaxis Program, The Department of
Paediatrics, Hospital for Sick Children, 555 University Ave, Toronto,
Canada, E-mail: thomas.eiwegger@sickkids.ca, Tel.: +1 416-813-7654 ext.
1862
Conflicts of Interest: AK and AL have nothing to disclose. TE
reports to act as local PI for company sponsored trials by DBV and
sub-investigator for Regeneron, holds grants from Innovation Fund
Denmark, CIHR outside the submitted work. He is Co-Investigator or
scientific lead in three investigator initiated oral immunotherapy
trials supported by the Food Allergy and Anaphylaxis Program SickKids
and serves as associate editor for Allergy. He/his lab received
unconditional/in-kind contributions from Macro Array Diagnostics and an
unrestricted grant from ALK. He holds advisory board roles for ALK.
Financial support: This work was supported by The Hospital for
Sick Children, The Food Allergy and Anaphylaxis Program at The Hospital
for Sick Children, and The Dr Lorus J And Dr Margery J Milne Scholarship
from Victoria University at the University of Toronto.
Statement of Author Contribution: All authors critically
reviewed the original articles (references 6 and 7) and wrote the News
& Views: Groundbreaking discoveries in Immunology article. All authors
contributed, revised, edited, and approved the final version of the
manuscript as submitted and agreed to be accountable for all aspects of
the work.
Keywords: emollient, atopic eczema, infancy
Abbreviations : food allergy, FA; filaggrin gene, FLG; atopic
dermatitis, AD; transepidermal water loss, TEWL; Barrier Enhancement for
Eczema Prevention, BEEP; Preventing Atopic Dermatitis and Allergies,
PreventADALL