Pseudomonas Aeruginosa Group (N=102)
The mean age of the patients at first isolation of P. aeruginosawas 5.83 ± 5.28 years. The mean duration from diagnosis to firstP. aeruginosa isolation was 4.16 ± 4.0 years. While 22 isolations (21.6%) from patients were successfully eradicated at 1 year after their first isolation, 56 (54.9%) had intermittent and 24 (23.5%) had chronic infection (Table 2).
The most common preferred eradication regimen in our clinic was intravenous amikacin and ceftazidime for 14 days. Table 2 shows the successful eradication rates by antibiotic regimens. The highest success rate among treatment regimens was 14 days ciprofloxacin PO + 28 days inhaled tobramycin by 62.5% vs. IV amikacin + ceftazidime by 20.3% but this difference was not statistically significant (p > 0.05). When IV amikacin + ceftazidime and other non-intravenous treatment regimens compared, there was not any statistically significant difference (p = 0.54). Results of antibiotic susceptibility testing showed 89.2% of isolations were sensitive to all antibiotics and 10.8% were resistant to one or more antibiotics. Patients received their eradication regimens according to the antibiotic susceptibility of their microbial cultures.
Sex, diagnosis age, age at isolation, BMI z-score, ΔF508 mutation, pancreatic insufficiency, CFRD, biliary-hepatic disease, dornase alfa use, inhaled corticosteroid use, ABPA, hospitalization in the preceding year and FEV1pp were not statistically significant as a predictor (p > 0.05) .
26 out of 102 patients were able to perform spirometry. The mean FEV1pp of eradicated group (n = 6) was 81.6 ± 9.02 and not eradicated group (n = 20) was 91.8 ± 18.65. This difference was not statistically significant (p > 0.05).