Methicillin-Resistant Staphylococcus Aureus Group (N=48)
The mean age of the patients at first isolation of MRSA was 7.66 ± 5.71
years. The mean duration from diagnosis to first MRSA isolation was 6.3
± 5.25 years. While 17 isolations (35.4%) were successfully eradicated
at 1 year, 17 patients (35.4%) had intermittent and 14 (29.2%) had
chronic infection (Table 2).
The most common MRSA eradication regimen used in our clinic was
intravenous teicoplanin for 14 days. The highest success rate among
treatments was 14 days oral Trimethoprim / Sulfamethoxazole (TMP/SMX) +
Rifampicin by 50% eradication success. Statistical analysis did not
show any difference between treatment regimens (p > 0.05).
Additionally, successful eradication rates were not significantly
different between intravenous and oral treatment groups (p = 0.57).
Sex, diagnosis age, age at isolation, BMI z-score, ΔF508 mutation,
pancreatic insufficiency, CFRD, biliary-hepatic disease, dornase alfa
use, inhaled corticosteroid use, ABPA, hospitalization rate in the
preceding year and FEV1pp were not statistically significant as a
predictor (p > 0.05).
20 out of 48 patients were able to perform spirometry. The mean FEV1pp
of patients in eradicated and not eradicated groups were 88.9 ± 21and
93.2 ± 13.1, respectively (p > 0.05).