Figure 5. Reversible inhibition of CYP3A4 by imatinib, gefitinib and sunitinib. Lineweaver–Burk plots for the inhibition of (A) imatinib, (C) gefitinib and (E) sunitinib on CYP3A4-mediated rivaroxaban metabolism; (B), (D) and (F) are the corresponding Dixon plots. The data represent the mean ± S.D. of triplicate experiments.
Table 2. Reversible inhibition kinetic parameters for rivaroxaban metabolism mediated by CYP2J2.