Figure 6. Effects of imatinib, sunitinib and gefitinib on
rivaroxaban metabolism by (A, B and C) CYP2J2 and (D, E and F) CYP3A4
with or without a 30-min pre-incubation in the presence of NADPH. Data
points are from three independent experiments.
Table
4. IC50 shifts initiated
by
pre-incubation of the three TKIs with NADPH in CYP2J2 incubations.