Figure 4. Reversible inhibition of CYP2J2 by imatinib and gefitinib. Lineweaver–Burk plots for the inhibition of (A) imatinib and (C) gefitinib (C) on CYP2J2-mediated rivaroxaban metabolism; (B) and (D) are the corresponding Dixon plots. The data represent the mean ± S.D. of triplicate experiments.