Figure 6. Effects of imatinib, sunitinib and gefitinib on rivaroxaban metabolism by (A, B and C) CYP2J2 and (D, E and F) CYP3A4 with or without a 30-min pre-incubation in the presence of NADPH. Data points are from three independent experiments.
Table 4. IC50 shifts initiated by pre-incubation of the three TKIs with NADPH in CYP2J2 incubations.