2.2 | Forward-in-time simulations with MetHis
Simulation of independent genetic markers under highly complex admixture
histories is often not trivial under the coalescent and using classical
existing software, as the coalescent generally assumes a different
pedigree for each independent locus instead of a single pedigree having,
in reality, produced all observed gene genealogies (see
Wakeley, King, Low, & Ramachandran,
2012). In this context, and because pedigrees are rarely known a
priori , we developed MetHis , a C open-source software package
available athttps://github.com/romain-laurent/MetHis.MetHis simulates independent SNPs or microsatellite markers in an
admixed population H under any version of the two-source populations
general model from Verdu and Rosenberg
(2011), and calculates summary-statistics
of interest to the study of complex admixture processes
(Supplementary Note S1 ).