2.2 | Forward-in-time simulations with MetHis
Simulation of independent genetic markers under highly complex admixture histories is often not trivial under the coalescent and using classical existing software, as the coalescent generally assumes a different pedigree for each independent locus instead of a single pedigree having, in reality, produced all observed gene genealogies (see Wakeley, King, Low, & Ramachandran, 2012). In this context, and because pedigrees are rarely known a priori , we developed MetHis , a C open-source software package available athttps://github.com/romain-laurent/MetHis.MetHis simulates independent SNPs or microsatellite markers in an admixed population H under any version of the two-source populations general model from Verdu and Rosenberg (2011), and calculates summary-statistics of interest to the study of complex admixture processes (Supplementary Note S1 ).