Re-exposure to LOCM and recurrence of HSR
A recurrent HSR was defined
as
an immediate HSR on subsequent re-exposure to LOCM while undergoing CT,
after a skin test had been performed. The LOCM administered at the time
of the HSR was regarded as the culprit agent. Change of LOCM was defined
as the use of an LOCM that had never been documented as a culprit agent
in the affected individual. A premedication protocol, based on the
severity of the HSR, was used according to institutional
guidelines,3 the details of which were previously
described.21 The incidence rate of recurrent immediate
HSRs was calculated by dividing the number of cases that had an HSR
within one hour after LOCM exposure by the number of all cases
undergoing enhanced CT during the study period.