Splenectomy abolished the protective effects of intranasal OT
against DSS-induced abnormal stress-related behavior and intestinal
inflammation
Stress-related behavior and colitis severity were similar between the
DSS-treated mice who had undergone splenectomy and the non-operated
animals. However, the protective effects of intranasal OT
administration, in particular, its effect on mobilization time,
immobilization time, weight change, colon length, disease activity
score, histological score, colon macroscopic damage score, were negated
(Fig.6A-I).