Intranasal OT ameliorated DSS-induced intestinal inflammation
In addition to improving abnormal stress-related behavior in the IBD
mice, intranasal OT treatment
ameliorated intestinal
inflammation. Furthermore, the intranasal OT treated mice
recovered their weight loss compared to the untreated IBD mice. Besides
the intranasal OT treated mice showed an increase in colon length,
decreased disease activity score, decreased histological score,
decreased colon macroscopic damage score, and a reduction in the levels
of TNF-α and IL-1β(Fig.3A-H). However, the intranasal OT+ intranasal
atosiban co-treated mice showed effects opposite to those observed in
the intranasal OT mice (Fig.3A-H).