Animals
The animals used in this experiment were in line with the “Guidelines for the Care and Use of Laboratory Animals” formulated by Shandong Province, China, and approved by Medical Ethics Committee for Experimental Animals, Shandong University School of Basic Medicine Sciences (ECAESDUSM 2014056). We separated wild-type C57BL6/J mice (male, 6–8 weeks of age) randomly. The investigators were blinded to the group allocation. Animals were euthanized by cervical dislocation after DSS administration.