Figure 3
Model: The antigen-specific immune response via CD23 in mice. IgE-antigen immune complexes (IgE-ICs) are endocytosed via CD23 by intestinal epithelial cell (IEC) or alveolar epithelial cell (AEC) which mediate transport of IgE-immune complexes into the circulation. Alternatively, immune complexes could also be formed directly in circulation. Uptake of IgE-immune complexes by B cells via CD23 allows transfer of IgE-ICs to dendritic cells in lymph nodes or spleen. This induces antigen-presentation on the surface of DCs in complex with the MHC complex to the T cells which promotes T cell proliferation and formation of antibodies.