Figure 1.
Regulation of IgE binding to CD23. A) Free IgE binds only weakly CD23 monomer whereas it binds much more strongly to oligomerized CD23 B) IgE-antigen immune complexes (IgE-IC) bind to CD23 much stronger than free IgE C) Binding of antigen-specific IgG to IgE-antigen complexes could enable complement fixation via CD21 and lead to co-aggregation of CD23 and CD21.