Figure 3
Model: The antigen-specific immune response via CD23 in mice.
IgE-antigen immune complexes (IgE-ICs) are endocytosed via CD23 by
intestinal epithelial cell (IEC) or alveolar epithelial cell (AEC) which
mediate transport of IgE-immune complexes into the circulation.
Alternatively, immune complexes could also be formed directly in
circulation. Uptake of IgE-immune complexes by B cells via CD23 allows
transfer of IgE-ICs to dendritic cells in lymph nodes or spleen. This
induces antigen-presentation on the surface of DCs in complex with the
MHC complex to the T cells which promotes T cell proliferation and
formation of antibodies.