FIGURE 1. Model illustrating the impact of IgG
antibodies on Type I hypersensitivity . Allergens are taken up by
antigen presenting cell which present processed antigen to
TH cells. TH cells help B cells to
produce IgE which binds to FcεRI on the surface of mast cell and
sensitize them. Subsequent production of allergen-specific IgG
antibodies which neutralizes allergens and/or engage the inhibitory
receptor FcγRIIb.