FIGURE 3. A cartoon illustrating a VLP nanoparticle-based vaccine against peanut allergy. The nanoparticles are packed with ssRNA, a TLR7/8 ligand, and display Ara h2 antigen. The natural pentameric IgM antibody can bind the VLPs with low affinity/high avidity. Such interaction contributes to the activation of classical complement cascade and binding of the formed immune-complex on FDCs for effective formation of GCs. This vaccine may induce high-affinity antibodies, drive antibody class-switching and establish long-lived memory. Abs; antibodies.