Administration of recombinant murine CXCL16 augmented inflammation after experimental sepsis induction
The leukocyte numbers in PLF from septic mice treated with recombinant murine CXCL16 were significantly greater than those of PBS-treated septic mice (Figure 5A), which comprised mainly neutrophils, monocytes/macrophages, and lymphocytes. Furthermore, CXCL16 administration enhanced the cytokine and chemokine response in nonsevere CLP, which led to a significant elevation of IL-6 TNF-α, KC and IL-27 in PLF and blood (Figure 5B).