Table 1. Independent factors predicting 28-day mortality in septic patients
Variable B Standard error Wald Degrees of freedom P value Odds ratio 95% confidence interval
CXCL16 0.007 0.003 4.013 1 0.039 1.004 1.000-1.010
PCT 0.013 0.006 3.303 1 0.074 1.011 0.999-1.023
CRP 0.004 0.008 0.857 1 0.304 1.006 0.983-1.033
SOFA 0.090 0.021 15.617 1 0.000 1.093 1.050-1.140
CRP: C-reactive protein; PCT: procalcitonin; SOFA: sequential organ failure assessment.
Supplementary Figure legends
Supplementary Figure 1 . Admission levels of soluble CXCL16 in serum samples from septic patients without bacteremia and with documented bacteremia
Supplementary Figure 2 . CXCL16 production was elevated in septic mice after cecal ligation puncture (CLP). C57BL/6 mice (n = 5 per group) were subjected to sham or nonsevere CLP with a 24-gauge needle, and then samples were collected for CXCL16 quantification by ELISA.p <0.001 when compared with sham control mice (Mann-Whitney U test).
Supplementary Figure 3 . The effects of recombinant murine CXCL16 on bacterial clearance in cecal ligation and puncture (CLP)-induced nonsevere sepsis. Dilutions of peritoneal lavage fluid (PLF) and blood were collected from CLP mice (n = 6) administered with or without recombinant murine CXCL16 (0.5 μg), and then were cultured on blood agar plates, and the number of bacterial colonies was determined as colony-forming unit (CFU).
Supplementary Figure 4 . Administration with anti-CXCL16 antibody did not affect bacterial clearance in CLP-induced severe sepsis. Dilutions of peritoneal lavage fluid (PLF) and blood were collected from CLP mice (n = 6) treated with or without anti-CXCL16 antibody (10 μg), and then were cultured on blood agar plates, and the number of bacterial colonies was determined as colony-forming unit (CFU).
Supplementary Table 1 . Characteristics of septic patients and healthy controls
Supplementary Table 2. Pathogens responsible for infections in the patients with sepsis
Supplementary Table 3. Baseline characteristics of septic survivors and non-survivors in the patients with sepsis
Supplementary Table 4. Correlations between CXCL16 and other cytokine levels in the patients with sepsis