The clinical role of CXCL16 in predicting 28-day mortality of septic patients
The AUC for prediction of 28-day mortality were calculated for CXCL16, CRP, PCT and SOFA scores. The AUC for CXCL16 on day of ICU admission was 0.717 ([95% CI] 0.497–0.939, p = 0.047, Figure 3), higher than the AUC for PCT (AUC = 0.617, [95% CI] 0.429–0.805, p= 0.231), and CRP (AUC = 0.521, [95% CI] 0.338–0.705, p = 0.819), but lower than the AUC for SOFA (AUC = 0.849, [95% CI] 0.715–0.982, p < 0.001).Furthermore, both CXCL16 (B = 0.007, OR = 1.004, p = 0.039) and SOFA score (B = 0.090, OR = 1.093, p = 0) on day of ICU admission were found to be independent predictors of 28-day mortality in the patients with sepsis, but PCT (B = 0.013, OR = 1.011, p = 0.074) and CRP (B = 0.004, OR = 1.006, p = 0.304) were not (Table 1).