Administration of recombinant murine CXCL16 augmented
inflammation after experimental sepsis induction
The leukocyte numbers in PLF from septic mice treated with recombinant
murine CXCL16 were significantly greater than those of PBS-treated
septic mice (Figure 5A), which comprised mainly neutrophils,
monocytes/macrophages, and lymphocytes. Furthermore, CXCL16
administration enhanced the cytokine and chemokine response in nonsevere
CLP, which led to a significant elevation of IL-6 TNF-α, KC and IL-27 in
PLF and blood (Figure 5B).