Introduction
As obesity became one of the most important threats to human health,
they also contribute to pregnancy complications, including preeclampsia,
gestational diabetes mellitus (GDM), preterm delivery, cesarean section
and small as well as large for gestational age neonates [1,2].
Additionally, obesity has been associated with adverse reproductive
outcomes [3-6].
An increasing number of obese women are receiving in vitro fertilization
(IVF). However, the etiology for impaired clinical outcomes in obesity
remains unclear. Obesity might influence clinical outcomes by reducing
oocyte quality, maturity and endometrial receptivity [7]. One of the
major limitations in the evaluation of BMI is that embryo chromosome
testing is often not performed. Most of the studies on effects of BMI on
IVF focused on the impact of adiposity on ovarian responsiveness during
ovarian hyperstimulation. In contrast, the effects of pre-pregnancy BMI
on risks of live birth in women undergoing frozen-thawed euploid embryo
transfer have not yet been adequately studied.
The objective of this study was to determine whether BMI is associated
with live birth in women with euploid embryo transfer. This was
performed to determine if euploid embryo from women with different BMI
have an altered potential.