Assessment of the anti-inflammatory and analgesic effects of tested drugs on an experimental model of inflammation
Effect on Paw edema
Sub-plantar injection of carrageenan produced a significant increase in paw thickness at 1,2,3,4 and 24 hours as compared to control normal group (figure 3). Indomethacin, glucosamine, and atorvastatin pretreated groups showed a statistically significant reduction of increased paw thickness induced by carrageenan starting from 1sthour then at 2,3,4, and 24 hours compared to the carrageenan treated group (figure 3). Atorvastatin pretreated group showed a statistically more significant reduction of the increased paw thickness than glucosamine pretreated groups. However, the reduction of the increased paw thickness in glucosamine or atorvastatin pretreated group significantly less than that produced by indomethacin, (figure 3).
Effect on nociceptive threshold
Sub-plantar injection of carrageenan in rats produced a statistically significant decrease in the nociceptive threshold at 1, 2, 3, 4, and 24 hours as compared to the control normal group. Indomethacin, glucosamine, or atorvastatin pretreated groups showed a statistically significant improvement in the reduced nociceptive threshold.The improvement found in the indomethacin pretreated group is significantly more than the other tested drugs Atorvastatin pretreated group showed a more significant improvement of the decreased nociceptive threshold than glucosamine treated groups at all-time intervals, (figure 4)