Assessment of the anti-inflammatory and analgesic effects of
tested drugs on an experimental model of inflammation
Effect on Paw edema
Sub-plantar injection of carrageenan produced a significant increase in
paw thickness at 1,2,3,4 and 24 hours as compared to control normal
group (figure 3). Indomethacin, glucosamine, and atorvastatin pretreated
groups showed a statistically significant reduction of increased paw
thickness induced by carrageenan starting from 1sthour then at 2,3,4, and 24 hours compared to the carrageenan treated
group (figure 3). Atorvastatin pretreated group showed a
statistically more significant reduction of the increased paw thickness
than glucosamine pretreated groups. However, the reduction of
the increased paw thickness in glucosamine or atorvastatin pretreated
group significantly less than that produced by indomethacin, (figure
3).
Effect on nociceptive threshold
Sub-plantar injection of carrageenan in rats produced a statistically
significant decrease in the nociceptive threshold at 1, 2, 3, 4, and 24
hours as compared to the control normal group. Indomethacin,
glucosamine, or atorvastatin pretreated groups showed a statistically
significant improvement in the reduced nociceptive threshold.The improvement found in the indomethacin pretreated group is
significantly more than the other tested drugs Atorvastatin pretreated
group showed a more significant improvement of the decreased nociceptive
threshold than glucosamine treated groups at all-time intervals, (figure
4)