What is already known about this topic?
- Monotherapy with antifungal agents is often preferred for the
treatment of invasive fungal infections (IFI) in pediatric patients,
however the combination of antifungals remains on the agenda as a
potential treatment strategy where monotherapy is insufficient.
- The efficacy and role of combination regimens in the treatment of IFI
in hematologic malignancies patients remains controversial.
- Previous studies of pediatric IFI are quite inadequate, and most
knowledge regarding the treatment of IFI is gathered from studies in
adults.What does this article add?
- The clinical experience data on the use of CAT in pediatric patients
with haematological malignancies with IFI, including the results of
efficacy and toxicity, were presented here.
- This study is remarkable considering the difficulties in planning
studies in pediatric patient group, limited data about IFI treatment
for clinical use, and no definitive accepted recommendation.