Introduction:
Solid Pseudopapillary tumors of the pancreas (SPTPs) are cystic and
solid neoplasms [1]. They are rare pancreatic neoplasms occurring
most commonly in females in the second or third decade and account about
0.17–2.7% of all pancreatic tumors [1, 2]. Many studies from 1961
until 2012 report that the most frequent symptom is abdominal pain, but
there are no symptoms in the rest of the cases and the diagnosis is made
through routine examination [3]. The monomorphic and bland
morphology of SPTP cells make it difficult to be differentiated from
other pancreatic tumors, especially Neuroendocrine tumors.
Immunohistochemistry (IHC) is a crucial factor in making the accurate
diagnosis. Here, we present a difficult-to-diagonse (SPTP) case due to
the almost subtotal cystic degeneraton and only scanty residual tumor
nests in the wall.