CONCLUSIONS
This meta-analysis demonstrated that 18.7% of the clinically
early-stage EOC patients are upstaged based on comprehensive surgical
staging. Patients with serous and high grade EOC have the highest risk
of being upstaged. Tumor positive uterus, cytology, peritoneal, omentum,
and appendix samples do occur frequently, but lead substantially less
frequent to a higher stage (1.6-8.5%) due to their overlap. This
meta-analysis provides a better insight to both patient and clinician
into the individual contribution of each component in surgical staging.