3.3.2 Regulation of JEV proteins on apoptosis
Firstly, E protein of JEV can induce apoptosis of HepG2 and Vero
cells(S-O, T-J, Stone, C-H, & J-J,
2006). Further studies have shown that JEV NS3 protein, as well as NS3
helicase and protease domains induce apoptosis through caspase-dependent
(caspase-9/-3) and -independent
pathways(Yiang et al., 2013). Research
by Yang et al.(T. C. Yang et al., 2009)
showed that JEV NS2B-NS3 induces the reduction of MMP and the release of
Cyt-c, leading to mitochondrial-mediated apoptosis. Moreover,
ROS-mediated activation of ASK1-p38 MAPK signaling pathway is also
related to NS2B-NS3 induced apoptosis. Recently results show that
JEV-NS5 not only participates in type Ⅰ IFN antagonism, but also plays
an anti-apoptotic effect by preventing IFN-β-induced p38
MAPK/STAT1-mediated apoptosis(Weng et
al., 2018).