Conclusion
This review is the first glimpse of flavivirus-induced apoptosis based
on a wide array of reported work concerning flavivirus infection. It
summarizes the current findings of flavivirus regulation of cell
apoptosis, including a vast panel of distinct pro-apoptotic and
anti-apoptotic mechanisms. The aftermath of virus invasion depend on the
initial dose and cell type, and it can also switch to different
mechanisms to exert its pathogenic effects in different cells. Taking
the above viewpoints into consideration will help us better understand
the mechanism of flavivirus-induced apoptosis and open a new gate for
further research on the pathogenesis of flavivirus. And more emphasis
needs to be put on studying the signaling pathways by which viruses
regulate cell survival pathways. Future research should focus on the
function of individual viral proteins, the host-virus interaction
between viruses and cellular proteins, and the regulation of non-coding
RNAs in viral infections.