Conclusion
This review is the first glimpse of flavivirus-induced apoptosis based on a wide array of reported work concerning flavivirus infection. It summarizes the current findings of flavivirus regulation of cell apoptosis, including a vast panel of distinct pro-apoptotic and anti-apoptotic mechanisms. The aftermath of virus invasion depend on the initial dose and cell type, and it can also switch to different mechanisms to exert its pathogenic effects in different cells. Taking the above viewpoints into consideration will help us better understand the mechanism of flavivirus-induced apoptosis and open a new gate for further research on the pathogenesis of flavivirus. And more emphasis needs to be put on studying the signaling pathways by which viruses regulate cell survival pathways. Future research should focus on the function of individual viral proteins, the host-virus interaction between viruses and cellular proteins, and the regulation of non-coding RNAs in viral infections.