Study outcomes
The primary composite outcome was maternal end-organ injury or death arising between 20 weeks’ gestation and up to 42 days after the index birth hospital discharge date. The list of conditions used to define maternal end-organ injury was based on the CPM developed by Bateman5 and validated by Metcalfe,6comprising 20 diagnoses and procedures, and consistent with Canadian perinatal surveillance definitions for severe maternal morbidity and death.17-19 (Table S1).
A secondary outcome was all-cause maternal mortality, from birth until 365 days postpartum, since previous work has shown a persistent increase in mortality risk beyond the early postpartum period.20,21