What’s already known about this topic?
The KIM-1 molecule, which was previously associated with acute kidney damage, is synthesized in proximal tubules after kidney damage and plays an important role in inflammation and immune response. Research has shown that the KIM-1 molecule, which is significantly synthesized in the lung and kidney, can be a receptor that facilitates the binding of SARS-CoV-2 to the cell surface through the IgV field and have put forward that it may be the cause of acute kidney damage in patients with Covid-19. Soluble urokinase plasminogen activator (suPAR), the dissolved form of urokinase plasminogen activator, has been another molecule thought to be responsible for acute kidney damage that may develop in Covid-19. However, suPAR may also play a role in fetal complications that may occur in the lungs and heart. suPAR plays an important role in the remodeling of tissues under inflammation and immune cell migration and activation.