Results:
Forty-three subjects were identified (23 continuous, 20 intermittent
dosing). There were no statistically significant differences between
groups in gender or gestational age, but higher baseline inspired oxygen
(FiO2) and VIS in the continuous group suggested a higher baseline
severity of illness (p =0.012). After sildenafil initiation, there
were no significant differences in the change in blood pressure, oxygen
saturation, FiO2, or VIS between groups, and no difference in the number
of subjects requiring discontinuation due to side effects (4 in the
continuous group, 1 intermittent, p =0.35). Eight subjects
(34.8%) in the continuous group and 3 (15%) in the intermittent group
died (p =0.024).