Dosing regimen AUC0-24h ss (μg·h/mL) AUC0-24h ss (μg·h/mL) AUC0-24h ss (μg·h/mL)
Severe renal impairment Normal renal function Ratio*
0.5 g q24h 94.4 (93.5 – 95.2) 45.3 (45.0 – 45.6) 2.08 (2.06 – 2.11)
0.5 g q48h 69.7 (69.2 –70.2) 1.54 (1.52 – 1.55)
0.25 g q24h 47.0 (46.6 – 47.5) 1.04 (1.03 – 1.05)
LD: 0.5 g MD: 0.25 g q24h 47.0 (46.6 – 47.4) 1.04 (1.03 – 1.05)