Monte Carlo Simulation and PK/PD Analysis
S. pneumoniae and S. aureus are among the most common CAP pathogens. The MIC distribution was excerpted from Wu’s study [21]. The MICs were determined using broth microdilution method according to the recommendation of Clinical and Laboratory Standards Institute. The MIC data used for cumulative fraction of response (CFR) analysis were based on discrete distribution according to the fractions of the isolates at each MIC category. AUC0-24h was generated based on logarithmic normal distribution to account for the variability in PK parameters. The PK/PD target wasf AUC0-24h/MIC = 47.05, where f indicates the free fraction of nemonoxacin (0.84). The CFR and the probability of target attainment (PTA) was calculated for four different dosing regimens of nemonoxacin. A dosage regimen was considered optimal if both PTA and CFR are greater than 90%. The simulation was performed on the data from simulated patients with Matlab software (R2018b, MathWorks, Inc., USA).