Adverse event No. of subjects (%)/No. of events No. of subjects (%)/No. of events
Severe RI (n = 10) Healthy controls (n = 10)
Any AE 8 (80)/11 2 (20%)/3
Prolonged QT interval
1 (10)
0
Urinary tract infection
2 (20)
0
Skin pruritus
1 (10)
0
Backache
1 (10)
0
Diarrhea
2 (20)
0
Increased Scr
2 (20)
0
Increased serum potassium
1 (10)
0
Increased CPK
1 (10)
0
Increased UA
0
1 (10)
Decreased INR
0
1 (10)
Shortened PT
0
1 (10)