Study Demographics
In the present study, 20 subjects with or without renal impairment were
enrolled. The participants, involving 14 males and 6 females, were
characterized by a wide range of ages (26–70 years) and body weights
(48.7–84.0 kg) (Table 1). The mean eGFR was 16.8 ± 6.0 ml/min/1.73
m2 in the renal impairment group (n = 10) and 107.3 ±
11.1 ml/min/1.73 m2 in the healthy control group (n =
10). Ten patients with severe renal impairment and two healthy subjects
reported concomitant medications during follow-up period. The three most
frequently used concomitant medications were amlodipine, sodium
bicarbonate, and compound α-ketoacid tablets.