Monte Carlo Simulation and PK/PD Analysis
S. pneumoniae and S. aureus are among the most common CAP
pathogens. The MIC distribution was excerpted from Wu’s study [21].
The MICs were determined using broth microdilution method according to
the recommendation of Clinical and Laboratory Standards Institute. The
MIC data used for cumulative fraction of response (CFR) analysis were
based on discrete distribution according to the fractions of the
isolates at each MIC category. AUC0-24h was generated
based on logarithmic normal distribution to account for the variability
in PK parameters. The PK/PD target wasf AUC0-24h/MIC = 47.05, where f indicates
the free fraction of nemonoxacin (0.84). The CFR and the probability of
target attainment (PTA) was calculated for four different dosing
regimens of nemonoxacin. A dosage regimen was considered optimal if both
PTA and CFR are greater than 90%. The simulation was performed on the
data from simulated patients with Matlab software (R2018b, MathWorks,
Inc., USA).