Abbreviations:
AE adverse event
AUC Area under curve
BMI body mass index
CFR cumulative fraction of response
CI confidence interval
CL clearance
CLr renal clearance
CrCl Creatinine clearance
ESRD end-stage renal disease
IIV inter-individual variability
MD maintaining dose
MRSA methicillin-resistant Staphylococcus aureus
OFV objective function value
PK/PD pharmacokinetics/pharmacodynamics
PPK population pharmacokinetics
PRSP penicillin-resistant Streptococcus pneumoniae
PTA probability of target attainment
TBW total body water
V1 central compartment volume
V2 peripheral compartment volume
VPC visual predictive check