LD: loading dose; MD: maintaining dose.
Data represent genomic mean and 90% prediction intervals (n = 1000).
* Comparison of exposures at steady-state
(AUC0-24h) between renal impairment and normal renal
function control groups administered at the standard dose (0.5 g
q24h).
Table 5. The cumulative fraction of response of nemonoxacin
against S. pneumoniae and S. aureus in community-acquired
pneumonia patients with normal renal function or severe renal impairment
after selective dose adjustment