Funding:
This study was funded by an MRC ‘Mechanism of human disease’ grant in collaboration with AstraZeneca (Grant Ref: MR/K015141/1). JAS is funded by the NIHR Manchester Biomedical Research Centre, a Wellcome Investigator in Science Award and is an NIHR Senior Investigator. HB is funded by a North West Lung Centre Pickering Fellowship. I.S currently supported by the European Respiratory Society RESPIRE 3 Marie Curie Fellowship Award (EU Horizon 2020 713406). I.S also reports grants from BMA James Trust Award, North West Lung Centre Charity, personal fees from Educational Talks for GPs, Travel Award for Conference Meetings, outside the submitted work.