LXA4 is produced in the nasal mucosa after nasal
allergen challenge
Quantification of LXA4 levels in nasal lavage samples
showed that LXA4 was produced in the nasal mucosa at
baseline and significantly increased in the nasal lavage fluid 1 hr
after allergen challenge (Fig 5, A ). Increased
LXA4 levels 1 hr after allergen challenge correlated
with the peak of nasal neutrophil infiltration (Fig 5, B ).
Interestingly, LXA4 levels also significantly increased
at 48 and 72 hrs post-allergen challenge when compared to baseline
levels and correlated at these time points to monocyte recruitment (Fig
5, C and D ).