Statistical analysis
Statistical analyses were conducted with GraphPad Prism 7. Continuous variables are presented as means and standard deviations (SD) or interquartile ranges (IQR) as appropriate, and the categorical variables are presented as counts and percentages. Demographic data and clinical characteristics were computed for all included participants and compared using chi-square or Fisher exact tests. Differences in clinical outcomes were compared using nonparametric Mann-Whitney tests or Kruskal-Wallis test, where appropriate. The correlation of treatment delay time interval and the score of SDS at V0 was evaluated by Spearman’s correlation analysis. P value of < 0.05 was considered as statistically significant.