Clinical outcomes and depressive symptoms were interlinked
We further split the cohort into a non-depressed and depressed group based on SDS scores to determine whether psychological status had an influence on clinical manifestations. In figure 4 ,A-E , it can be seen that for SCIT patients, the mean values of VAS (2.46 at V0; 2.10 at V1), dSS (0.57 at V0; 0.52 at V1), CSMS (at 1.0 V0; at 0.74 V1), and QoL (19.12 at V0; 17.57 at V1) in the non-depressed group are significantly lower than VAS (3.20 at V0; 2.83 at V1), dSS (0.74 at V0; 0.72 at V1), CSMS (1.5 at V0; 0.96 at V1), QoL (25.41 at V0; 25.86 at V1) in the depressed group (all P < 0.05).
The mean SDS score in patients undergoing SCIT was remarkably increased in patients with poorly controlled (42.16 at V0 and 39.65 at V1) and well controlled symptoms (40.54 at V0 and 41.2 at V1), when compared to those with completely controlled symptoms (32.24 at V0 and 29.58 at V1) (P < 0.01) (Figure 4, F ). The difference between clinical manifestations and clinical control in comparison to symptoms of anxiety are shown in figure S2 .