Assessment of clinical manifestations
The data were collected by paper- or web-based questionnaires for both V0 and V1. Children (aged under 14) completed the questionnaires with the help of their parents. The clinical manifestations assessed were symptoms (VAS13,14, dSS15), medication (dMS16, CSMS17), quality of life (QoL18,19), psychological burdens (SAS, SDS20,21) and clinical control of SCIT patients in the week prior to treatment (see details in supplement ).