Statistical analysis
Statistical analyses were conducted with GraphPad Prism 7. Continuous
variables are presented as means and standard deviations (SD) or
interquartile ranges (IQR) as appropriate, and the categorical variables
are presented as counts and percentages. Demographic data and clinical
characteristics were computed for all included participants and compared
using chi-square or Fisher exact tests. Differences in clinical outcomes
were compared using nonparametric Mann-Whitney tests or Kruskal-Wallis
test, where appropriate. The correlation of treatment delay time
interval and the score of SDS at V0 was evaluated by Spearman’s
correlation analysis. P value of < 0.05 was considered as
statistically significant.