Clinical outcomes and depressive symptoms were interlinked
We further split the cohort into a non-depressed and depressed group
based on SDS scores to determine whether psychological status had an
influence on clinical manifestations. In figure 4 ,A-E , it can be seen that for SCIT patients, the mean values of
VAS (2.46 at V0; 2.10 at V1), dSS (0.57 at V0; 0.52 at V1), CSMS (at 1.0
V0; at 0.74 V1), and QoL (19.12 at V0; 17.57 at V1) in the non-depressed
group are significantly lower than VAS (3.20 at V0; 2.83 at V1), dSS
(0.74 at V0; 0.72 at V1), CSMS (1.5 at V0; 0.96 at V1), QoL (25.41 at
V0; 25.86 at V1) in the depressed group (all P < 0.05).
The mean SDS score in patients undergoing SCIT was remarkably increased
in patients with poorly controlled (42.16 at V0 and 39.65 at V1) and
well controlled symptoms (40.54 at V0 and 41.2 at V1), when compared to
those with completely controlled symptoms (32.24 at V0 and 29.58 at V1)
(P < 0.01) (Figure 4, F ). The difference between
clinical manifestations and clinical control in comparison to symptoms
of anxiety are shown in figure S2 .