Abstract
Introduction: Early prediction of return of spontaneous
circulation (ROSC) for cardiac arrest (CA) patients is a major
challenge. This study’s goal was to investigate the value of the
carboxyhemoglobin (COHb) and methemoglobin (MetHb) levels as a
predictive marker for ROSC and prognostic marker for patients who
achieve ROSC.
Methods: A total of 241 adult patients (109 female, 132 male)
diagnosed as non-traumatic CA were included in the study. The patients
were divided into two groups based on whether they achieved ROSC.
Complete blood count parameters, routine biochemistry measurements,
coagulation parameters, and blood gas analysis, and cardiac markers
values were compared between the groups.
Results: COHb levels were significantly lower in the non-ROSC
group (0.71 ± 0.57%) than in the ROSC group (0.95 ± 0.76%) and in the
non-survival group (0.78 ± 0.53%) compared to the survivor group (1.45
± 1.31%) (p =0.002, 0.022 respectively). There was no significant
difference between the ROSC and non-ROSC groups and survivor group and
non-survivor groups in terms of MetHb levels (p = 0.769 and 0.668,
respectively).
Conclusions: COHb levels in the blood gas analysis at the time
of admission could be used as a predictive marker for ROSC and
prognostic marker for the patients who achieved ROSC.
Keywords: Carboxyhemoglobin, cardiac arrest, methemoglobin,
ROSC, prognosis