Acknowledgement
We thank Dr. Thomas D. Mayers for the critical reading of the manuscript. This work was supported by the Research Program for Intractable Diseases, Health and Labor Sciences Research Grants from the Ministry of Health, Labor and Welfare, Japan, and Grant-in Aid for Scientific Research (C) from the Ministry of Education, Culture, Sports, Science and Technology and Japan Society for the Promotion of Science (JSPS). This work was also supported by AbbVie Japan Research Grant.