Figure 6. Schematic diagram of potential
Tr17 cells increased in LNs before induction of CIA and Tr17 cells
increased during the clinical course of CIA and accumulated in inflamed
joints. Tr17 cells highly expressed CD25, CTLA4, GITR, and ICOS
molecules and over-produced IL-10. Tr17 cells suppressed proliferation
of conventional T cells. Tr17 cells played a crucial role in the
regulation of autoimmune arthritis trough infiltration into ankle
joints.