Background and Purpose:
Cholinergic neurotransmission is a key signal pathway in the peripheral
nervous system (PNS) and in several branches of the central nervous
system (CNS). Despite the fact that it has been studied extensively for
a long period of time, some aspects of its regulation still have not yet
been established. One is relationship between nicotine-induced
autoregulation of acetylcholine (ACh) release with changes in the
concentration of presynaptic calcium levels.