Animals
Mice BALB/C (20-23g, 2-3 months old) of either sex were used in this study. All animal care and experimental protocol met the requirements of the European Communities Council Directive 86/609/EEC and was approved by the Ethical Committee of Kazan Medical University. Animals were housed in group of 10 animals divided by gender inside plastic cages with plenty of food (standard mice chow) and water ad libitum . The temperature (22°C) of the room was kept constant and 12-h light/dark cycle was imposed. Animal studies are reported in compliance with the ARRIVE guidelines (Percie du Sert et al., 2020) and with the recommendations made by the British Journal of Pharmacology (Lilley et al., 2020).