Figure Legends
Figure 1: 1A: Elevated levels of IL-8 at 6 hours post-op are correlated with neurocognitive decline at postoperative day 4 (POD4, p=0.04). 1B: Postoperative leukocytosis (WBC ≥ 10.5x103mm) was associated with NCD at POD4 when compared to their baseline function (p=0.03). 1C: HbA1c levels are not correlated with NCD at POD4 (p=0.973). 1D: Elevated fasting glucose levels (>126mg/dL) are not associated with NCD at POD4 (p=0.910). 1E: Among patients with normal HbA1c levels, elevated fasting glucose levels are also not associated with NCD. 1F: Glucose levels during CPD are not associated with postoperative NCD (p=0.639). NCD=neurocognitive decline, POD4=postoperative day 4, CPD=cardiopulmonary bypass
Figure 2: Postoperative genetic regulation in patients with or without neurocognitive decline. Patients who experienced neurocognitive decline had an upregulation of 445 genes and a downregulation of 40 genes on POD4.
Figure 3: Post-operative genetic regulation in patients with diabetes with or without neurocognitive decline. Patients with diabetes who experienced NCD at POD demonstrated upregulation of 277 genes and downregulation of 220 genes compared to those patients with diabetes but no neurocognitive decline.
Figure 4: Postoperative genetic regulation between patients with and without diabetes after cardiopulmonary bypass demonstrates minimal differences.
Figure 5: Postoperative genetic regulation in patients with neurocognitive decline with or without diabetes. Within the subset of patients with NCD, those with diabetes upregulated 121 genes and downregulated 159 genes compared to patients who also had NCD but not diabetes.