3.5∣25-μg DNA patches ameliorated For t 2-induced scratch behaviors with both therapeutic as well as prophylactic approaches
For midge-allergic patients, the primary goal of treatment is to provide relief from the annoying itchy allergic reaction to the midge bite. The For t 2 DNA patches at 25-μg significantly ameliorated midge allergen-challenge-induced scratch bouts either in mice already sensitized to the midge (therapeutic) or before being sensitized (prophylactic) compared with the non-vaccinated groups, resulting in some instances to numbers of scratch bouts as low as those observed in the non-sensitized groups (NS), as shown in Fig 2A and 2B, respectively.