3.6∣25-μg DNA vaccine patches suppressed total IgE production
and increased For t 2-specific IgG2a with both therapeutic and
prophylactic approaches
The left panels of Figure 3A and 3B show a scatter plot for the final
total IgE profiling from an individual mouse at week 6 or 8,
respectively. For both the therapeutic and the prophylactic approach,
SV25-T and SV25-P groups showed significantly less total IgE production
compared with the NV-T and NV-P groups. Moreover, the SV25-T group had
higher level of For t 2-specific IgG2a antibodies than the respective
non-vaccinated groups at week 6. The levels of For t 2-specific IgG2a at
SV25-P group reached statistical significance at week 8 (right panels of
Figure 3A and 3B).