Limitations and strengths
Our study is limited by the methodological quality of included studies and by the presence of significant inconsistency and publication bias that was observed among studies that presented data that were used for the analysis of investigated primary outcomes. However, we believe that with the use of sensitivity and meta-regression analysis we were able to fill the gaps in current research, and underline that the differences in serum LDH values among the various groups of pregnancy associated disorders are minimal and do not need further investigation. A significant limitation of our study is also the lack of a diagnostic and predictive accuracy analysis that would help determine the actual value of serum LDH in detecting preeclampsia and differentiating patients at risk of developing adverse effects (maternal or neonatal).