Clinical Implications
In patients with CS, the echocardiographic response following a CRT upgrade should be carefully evaluated because of the complex etiology and effect of the corticosteroids. The echocardiographic response to an upgrade to CRT is not necessarily for predicting the long-term prognosis in patients with CS. The corticosteroid therapy should be preceded by an upgrade to CRT in CS patients who have cardiac dysfunction and are eligible CRT therapy.