Conclusion
Among the three included regions of Hungary, significant differences were detected in the incidence of AMI, TIT of patients with STEMI and their mortality rates. Additionally, logistic regression analysis confirmed the independent prognostic significance of the region regarding 30-day mortality; however, further research is necessary to explore the data of smaller regional units with respect to infarction treatment, with particular regard to accessing up-to-date care and secondary prevention.
Acknowledgments: We would like to thank all participants of HUMIR and Editage (www.editage.com) for English language editing.
Conflict of Interest: none declared.
Data availability: The data from HUMIR that support the findings of this study are available on reasonable request to the corresponding author.
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Title and table legends:
Table 1. Regional distributions of different type of myocardial infarctions, medical history, and comorbidities
Legend: In the right column of the results table, the p-value of the Chi-squared test is represented, i.e. whether the value of the examined factors (e.g. the ratio of myocardial infarction) depends on the value of another factor (e.g. in the present case, the region). We then added the post-hoc test results after the p-value in brackets (regionally differentiating between leftover tag values and p-values to show whether the given region is significantly different in terms of frequency from the whole).
Table 2. Patient delay, prehospital response time and types of infarction per region
Table 3. 30-day and 1-year mortality of men and women in different types of myocardial infarction treated with and without PCI, per region
Legend: The first p value belongs to the chi-squre test, while in brackets the results of the post hoc tests are to be found
Title and figure legends:
Figure 1. The regions and their population data
Legend: WR: Western Region, CR: Central Region, ER: Eastern Region
Figure 2.a Time intervals of the emergency care process, NSTEMI
Legend: Arrival to location (T1), treatment on-site (T2) and time interval between transferring the patient from the original location to the hospital (T3)
Figure 2.b Time intervals of the emergency care process, STEMI
Legend: Arrival to location (T1), treatment on-site (T2) and time interval between transferring the patient from the original location to the hospital (T3)
Figure 3. Pharmacological treatment for secondary prevention recommended upon hospital discharge per region.
Legend: WR: Western Region, CR: Central Region, ER: Eastern Region, RAAS: renin–angiotensin–aldosterone system, PI: platelet inhibitors
Figure 4. Kaplan–Meier survival curves by regions, NSTEMI
Legend: Survival probabilities (lines and dots) and their confidence intervals (vertical sections) are represented, per region
Figure 5. Kaplan–Meier survival curves by regions, STEMI
Legend: Survival probabilities (lines and dots) and their confidence intervals (vertical sections) are represented, per region
Figure 6. Results of Cox Proportional Hazards Regression Model, NSTEMI
Legend: First column contains names of variables (the factors examined), second column shows the mortality period, third and fourth column show hazard ratio (HR) values in diagram and in tabulated formats (hazard ratio denoted by with square and their confidence intervals denoted by horizontal lines), fifth column shows the probability (P) values (a variable was significant where P value was below 0.05, it is denoted by 0)
Figure 7. Results of Cox Proportional Hazards Regression Model, STEMI
Legend: First column contains names of variables (the factors examined), second column shows the mortality period, third and fourth column show hazard ratio (HR) values in diagram and in tabulated formats (hazard ratio denoted by with square and their confidence intervals denoted by horizontal lines), fifth column shows the probability (P) values (a variable was significant where P value was below 0.05, it is denoted by 0)