Infectious complications and SSR
No differences in CRP levels according to the presence of VO were observed in patients with infectious complications (Figure 2b). Univariate analysis in this subgroup of patients did not reveal any association with abnormal CRP values in the post-operative period, so that multivariate analysis was unnecessary (Supplementary Table 1). Further analysis was therefore conducted only for patients without infectious complications. In this subgroup, CRP values were significantly higher in VO compared to non-VO patients on POD1, POD2, POD3 and POD5 (Figure 2a). Univariate analysis showed a positive correlation between CRP from POD 1 to 3, and VO (Supplementary Table 2), with the highest coefficient on POD2 (β=0.200; p=0.001). In multivariate analysis (Table 5), VO was confirmed as independent risk factor for increased CRP values between POD1-3. Other factors associated with high CRP values were conversion to open surgery (POD1-2) and time of surgery (POD 1-4). ERAS enrollment was independently associated with lower CRP values on POD2, POD3 and POD5.