Assessment of POD3 CRP cut-off values
Considering the outcome of infectious complications, ROC curve analysis revealed an AUC of 0.86 (95% CI: 0.78-0.95, p<0.001), thus confirming the clinical significance of measuring CRP on POD3, as reliable predictor of infectious complications. In the overall population, the optimal cut-off was 134 mg/L, associated with 80% sensitivity and 78.9% specificity. Even considering VO and non-VO separately, CRP value on POD3 was an efficient predictor of infectious complications, displaying an AUC value >0.85 (Figure 3). According to the Youden’s index, the optimal cut-off value of CRP on POD3 was 136 mg/dL (87.5% sensitivity and 88% specificity) for non-VO patients, and 154 mg/dL (83.3% sensitivity and 81.2% specificity) for VO patients, respectively.