Conclusion:
Based on the varying patient presentations encountered in the setting of myelomatous involvement of body cavities, it can be stressed that ascitic or pleural fluid cytology is an important diagnostic method in the presence of atypical MM symptoms. Cytological examination may be useful in early diagnosis of a plasma cell neoplasm. It is also helpful in identifying extra-medullary progression in some cases where it is indicative of an aggressive form of the disease requiring prompt evaluation and treatment.